science Clinical Focus

Retinitis Pigmentosa (RP)

A genetic eye disorder causing progressive vision loss. Learn how scientific advancements and 9-cis retinal supplementation are bringing new hope to patients worldwide.

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Understanding RP

Retinitis pigmentosa (RP) is a group of rare, genetic disorders that involve a breakdown and loss of cells in the retina—the light-sensitive tissue that lines the back of the eye. Common symptoms include difficulty seeing at night and a progressive loss of peripheral vision.

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The Mechanism

Mutations in multiple genes can cause RP. Many of these genes hold instructions for making proteins needed by photoreceptors. When photoreceptors degenerate, the visual cycle is disrupted, preventing the eye from effectively converting light into signals sent to the brain.

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Role of 9-cis

Research suggests that augmenting the phototransduction cascade with 9-cis retinal can bypass certain genetic blocks in the visual cycle. As an analog to 11-cis retinal, it acts phenomenally to restore light sensitivity and support remaining healthy retinal structures.

Research Library

Access our curated database of clinical studies organized by health domain and year of publication.

visibility 9 CIS BETA CAROTENE

Pharmacotherapy of retinal disease with visual cycle modulators.

9-cis-beta-carotene retinitis pigmentosa research shows promise for protecting vision. Learn about clinical trials, how it works, and why it's not yet available.

Author Hussain, Rehan M and Gregori, Ninel Z and Ciulla, Thomas A and Lam, Byron L
Journal Expert opinion on pharmacotherapy
Year 2018
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Educational Purpose Only — The research and biomedical studies provided on this page are for informational and educational purposes only. They are intended to explain the mechanism of the 9-cis molecule. They are not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.