science Clinical Focus

Atherosclerosis

The buildup of plaques within arterial walls. Discover how carotenoid-derived retinoids influence vascular health and combat oxidative stress at the cellular level.

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Plaque Formation

Atherosclerosis is characterized by the accumulation of cholesterol-laden macrophages in the arterial wall, leading to the formation of restrictive plaques that impair blood fluidity and cardiovascular efficiency.

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Inflammatory Pathways

Chronic inflammation fundamentally drives the progression of atherosclerosis. Oxidized lipoproteins trigger immune responses, causing white blood cells to migrate and further destabilize the vascular endothelium.

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Retinoid Signaling

Scientific literature indicates that Retinoid X Receptor (RXR) agonists like 9-cis retinoic acid can dramatically modulate lipid metabolism and enhance macrophage cholesterol efflux, offering protective enzymatic pathways.

Research Library

Access our curated database of clinical studies organized by health domain and year of publication.

visibility 9 CIS BETA CAROTENE

9-cis β-Carotene Increased Cholesterol Efflux to HDL in Macrophages.

9-cis-beta-carotene atherosclerosis research reveals how this natural isomer may improve HDL function and cholesterol efflux through unique RXR activation pathways.

Author Bechor, Sapir and Zolberg Relevy, Noa and Harari, Ayelet and Almog, Tal and Kamari, Yehuda and Ben-Amotz, Ami and Harats, Dror and Shaish, Aviv
Journal Nutrients
Year 2016
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Educational Purpose Only — The research and biomedical studies provided on this page are for informational and educational purposes only. They are intended to explain the mechanism of the 9-cis molecule. They are not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.